June 24, 2021

Metastudy shows little possibility for variants to escape human immune system

The following is a pre-proof of an article which has been accepted for publication to the journal Cell Host and Microbe. It was written by Alba Grifoni, John Sidney, Randi Vita, Bjoern Peters, Shane Crotty, Daniela Weiskopf and Alessandro Sette.

The metastudy involved the review of 25 researches that investigated and identified SARS-CoV-2-derived T-cell epitopes in humans (note that epitopes are fragments of a pathogen that stimulates an immune response[1]see more at https://www.britannica.com/science/epitope). They assessed how each of the 25 researches was done, as well as attempt to determine the correlation between the number of epitopes identified and the size of antigen provenance.

The results of the study show that the human immune system can identify at least 1,400 different SARS-CoV-2 epitopes. The researchers conclude, “The fact that already more than 1,400 epitopes have been identified, also considering that many HLA alleles[2]how the T-cells recognize an epitope and regions of the SARS-CoV-2 proteome[3]technical term for the SARS-CoV-2 protein which can be expressed by a genome, cell, or tissue at a certain time are relatively less studied, highlights that a large breadth of epitopes are recognized in human populations, making it unlikely that SARS-CoV-2 variants might escape T cell recognition at the population level”.

Editor’s Note: This article strengthens the case for natural immunity. Whereas the vaccines were only designed to develop immune reactions to certain epitopes in the spike protein, the human immune system already has the capacity to identify enormous numbers of epitopes. Indeed, this could be the very reason why most people only develop mild COVID disease. [In an earlier article, Dr. Bryam Bridle also said that natural immunity is superior to vaccine-induced immunity for this same reason, see Pro-vaccine immunologist: “I would probably prefer to have natural immunity”].

This essentially means that even without the vaccines, the immune system will be able to develop the capacity to recognize future variants of SARS-CoV-2 [there are already studies about this, see New study: T-cells induced by COVID infection can respond to new SARS-CoV-2 variants and Our immune system evolves to fight coronavirus variants].

The conclusion of this research pushes us to ask:

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Sources

Sources
1 see more at https://www.britannica.com/science/epitope
2 how the T-cells recognize an epitope
3 technical term for the SARS-CoV-2 protein which can be expressed by a genome, cell, or tissue at a certain time

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