In this December 14, 2020 notice, the World Health Organization has finally acknowledged the increasing reports of false positive SARS-CoV-2 results. The memo says: “…the probability that a person who has a positive result is truly infected with SARS-CoV-2 decreases as positive rate decreases, irrespective of the assay specificity. Therefore, healthcare providers are encouraged to take into consideration testing results along with clinical signs and symptoms, confirmed status of any contacts, etc.”
WHO says that a manual readjustment of the PCR positivity threshold must be done to account for background noise in specimens with high cycle thresholds. The WHO adds, “In some cases, the [information for use or] IFU will state that the cut-off should be manually adjusted to ensure that specimens with high Ct values are not incorrectly assigned SARS-CoV-2 detected due to background noise”.
Editor’s Note: This is what several experts have been saying for months – high cycle thresholds can lead to false positives as the PCR test can replicate any DNA material. Moreover, one cannot say that a person has COVID-19 if that person exhibits no symptoms [see Swiss immunologist explains existing immunity to SARS-CoV-2 and the myth of asymptomatic carriers, also read some articles about PCR testing in article category Are the tests accurate?]. Now, that the WHO has acknowledged the need to look at clinical signs and symptoms of the disease before saying that a person has COVID-19, what shall we make of all the “asymptomatic” cases? How will governments take this WHO notice into consideration in adjusting for their PCR testing strategies?
One thing to notice though in this recent release from the WHO is that there is no real attempt to guide organizations in limiting the cycle thresholds (Ct), despite science showing that Cts beyond 35 will return more false positives. Is this WHO notice a real guideline, or is the WHO just covering the bases in preparation for its defense in the lawsuits being planned against it? [See Legal experts plan to sue WHO, governments for crimes against humanity].
Click the button below if you wish to read the article on the website where it was originally published.
Click the button below if you wish to read the article offline.